The fifth season of the DC Super Hero Girls webseries was released on August 2 and ended on December 27, 2018 with a total of 24 episodes. This season featured an unreleased two-part Season 4 webisode "Fortress of Solidarity".
- Yvette Nicole Brown as Bumblebee's Mom (uncredited) / Principal Waller
- Greg Cipes as Beast Boy
- Jessica DiCicco as Star Sapphire
- John DiMaggio as Anti-Hall Monitor / Darkseid / Dr. Seid / Vice Principal Grodd / Wildcat
- Teala Dunn as Artemiz / Bumblebee
- Anais Fairweather as Supergirl
- Nika Futterman as Cheshire / Hawkgirl
- Grey Griffin as Robin / Wonder Woman
- Misty Lee as Big Barda / Mad Harriet
- Erica Lindbeck as Mera
- Danica McKellar as Frost
- Matthew Mercer as Captain Cold
- Cristina Milizia as Jessica Cruz (uncredited)
- Cristina Pucelli as Catwoman / Miss Martian / Violet Lantern Ring
- Kevin Michael Richardson as Trigon (uncredited)
- Ashlyn Selich as Batgirl / Speed Queen
- Stephanie Sheh as Bleez / Katana
- Tara Strong as Harley Quinn / Poison Ivy / Raven
- Fred Tatasciore as Killer Croc / Kryptomites
- Hynden Walch as Starfire
- Mae Whitman was unavailable to reprise her role as Batgirl and the Speed Queen, and was replaced by Ashlyn Selich who previously voiced the Batgirl in the LEGO shorts and films.
- "Fortress of Solidarity" was originally going to be released as two separate parts in the fourth season. But was instead shown together in this season just like fellow multi-part episodes "All Pets Are Off", "For the Girl Who Has Everything" and "My So-Called Anti-Life". Only "Spell-shocked" aired its respective parts separate.
- This is the first season to feature a new animated format.
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