Karen is a favorite target of school bullies Doris Zeul and Leslie Willis due to her small stature. To boost the effects of her weightlifting, Doris injects herself with a serum stolen from her parents' lab, which allows her to transform into the hulking and muscle-bound Giganta when she gets angry. Karen shows her friends an upgrade to her battle armor, but its new growth function fails and causes her to shrink instead. She, Batgirl, Supergirl, and Wonder Woman find Giganta tearing up the mall, where she easily holds off the other three as Karen suits up and frantically tries to fix her armor. The growth feature malfunctions again, but Bumblebee uses her tiny size to harass Giganta and trick her into knocking herself out. The next day at school, Karen shows off new confidence in standing up to Doris and Leslie.
This episode shows how Karen upgraded her suit and how Doris becomes Giganta.
Although this is the twelfth episode aired, it is chronologically the fifth according to executive producer Lauren Faust.
The title of the episode is a reference to the band They Might Be Giants.
The techno remix of the classical song Flight of The Bumblebee by Nikolai Rimsky-Korsakov was reused from the short "Plight of The Bumblebee."
When Giganta broke the basketball table and throw, the Wilhelm Scream can be heard.
This is the second episode to use the Wilhelm Scream.
The only point is that the suit dazzled in episodes before the start of the episode is Meet The Cheetah, Beeline and Shock It To Me and even she, Doris Zeul, transformed herself into Giganta by the amount of the weird that appeared before she turned into Beeline.
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